| Registro completo |
| Provedor de dados: |
Genet. Mol. Biol.
|
| País: |
Brazil
|
| Título: |
Association study of folate-related enzymes (MTHFR, MTR, MTRR) genetic variants with non-obstructive male infertility in a Polish population
|
| Autores: |
Kurzawski,Mateusz
Wajda,Anna
Malinowski,Damian
Kazienko,Anna
Kurzawa,Rafal
Drozdzik,Marek
|
| Data: |
2015-03-01
|
| Ano: |
2015
|
| Palavras-chave: |
MTHFR
MTR
MTRR
Polymorphism
Infertility
|
| Resumo: |
Spermatogenesis is a process where an important contribution of genes involved in folate-mediated one-carbon metabolism is observed. The aim of the present study was to investigate the association between male infertility and the MTHFR (677C > T; 1298A > C), MTR (2756A > G) and MTRR (66A > G) polymorphisms in a Polish population. No significant differences in genotype or allele frequencies were detected between the groups of 284 infertile men and of 352 fertile controls. These results demonstrate that common polymorphisms in folate pathway genes are not major risk factors for non-obstructive male infertility in the Polish population.
|
| Tipo: |
Info:eu-repo/semantics/report
|
| Idioma: |
Inglês
|
| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572015000100042
|
| Editor: |
Sociedade Brasileira de Genética
|
| Relação: |
10.1590/S1415-475738120140179
|
| Formato: |
text/html
|
| Fonte: |
Genetics and Molecular Biology v.38 n.1 2015
|
| Direitos: |
info:eu-repo/semantics/openAccess
|
